ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in triple negative breast cancer cells.

ABSTRACT:

Background

Triple-Negative Breast Cancer is particularly aggressive, and its metastasis to the brain has a significant psychological impact on patients' quality of life, in addition to reducing survival. The development of brain metastases is particularly harmful in triple-negative breast cancer (TNBC). To date, the mechanisms that induce brain metastasis in TNBC are poorly understood.

Methods

Using a human blood-brain barrier (BBB) in vitro model, an in vitro 3D organotypic extracellular matrix, an ex vivo mouse brain slices co-culture and in an in vivo xenograft experiment, key step of brain metastasis were recapitulated to study TNBC behaviors.

Results

In this study, we demonstrated for the first time the involvement of the precursor of Nerve Growth Factor (proNGF)

SUBMITTER: Cicero J 

PROVIDER: S-EPMC10710730 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature