Gene polymorphism of MTHFR rs1801133 and susceptibility to childhood leukemia in Chinese population.

ABSTRACT:

Background

The purpose of this study is to investigate the genotype and allele distribution of MTHFR rs1801133 in the Chinese population, and to analyze the relationship between gene polymorphism of MTHFR rs1801133 and risk of childhood leukemia.

Methods

Blood samples and clinical data of childhood leukemia cases (n=1132) and age-matched healthy controls (n=1053) were collected. Genotypes and allele distribution of MTHFR rs1801133 were detected by PCR-RFLP. Logistic regression model was generated to analyze the relation between MTHFR rs1801133 and susceptibility to childhood leukemia and the chemotherapy response.

Results

Age, sex, BMI and family history of tumor were comparable between childhood leukemia cases and healthy controls. Genotypes and allele distribution o

SUBMITTER: Peng Y 

PROVIDER: S-EPMC10710815 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature