Flipping the switch: dynamic modulation of membrane transporter activity in bacteria.

ABSTRACT: The controlled entry and expulsion of small molecules across the bacterial cytoplasmic membrane is essential for efficient cell growth and cellular homeostasis. While much is known about the transcriptional regulation of genes encoding transporters, less is understood about how transporter activity is modulated once the protein is functional in the membrane, a potentially more rapid and dynamic level of control. In this review, we bring together literature from the bacterial transport community exemplifying the extensive and diverse mechanisms that have evolved to rapidly modulate transporter function, predominantly by switching activity off. This includes small molecule feedback, inhibition by interaction with small peptides, regulation through binding larger signal transduction proteins

SUBMITTER: Elston R 

PROVIDER: S-EPMC10710835 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature