Comparative analysis of two timepoints on [¹⁸F]FAPI-42 PET/CT in various cancers.

ABSTRACT:

Purpose

This study aimed to assess the biodistribution, detection rate, and uptake of the [¹⁸F]FAPI-42 at two distinct time intervals.

Methods

This prospective study enrolled 60 consecutive patients (median age 59; range 35-74) referred to [¹⁸F]FAPI-42 PET/CT. [¹⁸F]FAPI-42 PET/CT was performed early and late timepoint after tracer injection for staging or restaging. Positive lesions specified for anatomic locations (primary or recurrent tumor, LN metastasis and other metastasis) by visual analysis at both timepoints. Semiquantitative analysis of the tracer activity in lesions as well as normal tissues at both time points were measured and compared. In a subgroup analysis, eleven patients underwent 2-[¹⁸F]FDG PET/CT within 1 week, t

SUBMITTER: Mu X 

PROVIDER: S-EPMC10710973 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature