Inhaled drug delivery: a randomized study in intubated patients with healthy lungs.

ABSTRACT:

Background

The administration technique for inhaled drug delivery during invasive ventilation remains debated. This study aimed to compare in vivo and in vitro the deposition of a radiolabeled aerosol generated through four configurations during invasive ventilation, including setups optimizing drug delivery.

Methods

Thirty-one intubated postoperative neurosurgery patients with healthy lungs were randomly assigned to four configurations of aerosol delivery using a vibrating-mesh nebulizer and specific ventilator settings: (1) a specific circuit for aerosol therapy (SCAT) with the nebulizer placed at 30 cm of the wye, (2) a heated-humidified circuit switched off 30 min before the nebulization or (3) left on with the nebulizer at the inlet of the heated-humidifier, (4) a conve

SUBMITTER: Dugernier J 

PROVIDER: S-EPMC10710976 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature