Differential molecular profiles and associated functionalities characterize connective tissue grafts obtained at different locations and depths in the human palate.

ABSTRACT: The present study aimed to assess the molecular profiles of subepithelial connective tissue grafts (CTGs) obtained at different locations and depths in the human palate. Sixty-four CTGs belonging to anterior deep (AD), anterior superficial (AS), posterior deep (PD), and posterior superficial (PS) groups were subjected to RNA-Sequencing and their transcriptomes were analyzed computationally. Functional correlations characterizing the CTG groups were validated by cell biological experiments using primary human palatal fibroblasts (HPFs) extracted from the CTGs. A clearly more pronounced location-dependent than depth-dependent difference between the grafts, with a minimal number of genes (4) showing no dependence on the location, was revealed. Epithelial, endothelial, and monocytic cell migra

SUBMITTER: Asparuhova MB 

PROVIDER: S-EPMC10711016 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature