Metabolic reprogramming involves in transition of activated/resting CD4⁺ memory T cells and prognosis of gastric cancer.

ABSTRACT:

Background

Little is known on how metabolic reprogramming potentially prompts transition of activated and resting CD4⁺ memory T cells infiltration in tumor microenvironment of gastric cancer (GC). The study aimed to evaluate their interactions and develop a risk model for predicting prognosis in GC.

Methods

Expression profiles were obtained from TCGA and GEO databases. An immunotherapeutic IMvigor210 cohort was also enrolled. CIBERSORT algorithm was used to evaluate the infiltration of immune cells. The ssGSEA method was performed to assess levels of 114 metabolism pathways. Prognosis and correlation analysis were conducted to identify metabolism pathways and genes correlated with activated CD4⁺ memory T cells ratio (AR) and prognosis. An AR-related met

SUBMITTER: Sun Y 

PROVIDER: S-EPMC10711070 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature