Multifunctional ADM hydrogel containing endothelial cell-exosomes for diabetic wound healing.

ABSTRACT: Non-healing wound, with limited treatment options, remains a prevalent complication of diabetes mellitus. The underlying causes wherein include oxidative stress injury, bacterial infection, cellular dysfunction, and persistent inflammation. Acellular Dermal Matrix (ADM), a wound dressing composed of natural extracellular matrix and abundant bioactive factors, has been successfully developed to treat various wounds, including burns and diabetic ulcers. Protocatechualdehyde (PA) & trivalent iron ion (Fe³⁺) complex (Fe³⁺@PA) exhibits potential antioxidant and antibacterial properties. In this study, we developed a dual hydrogel network by combining Fe³⁺@PA complex-modified ADM with light-cured gelatin (GelMA), supplemented with exosomes derived from human umbi

SUBMITTER: Xiang K 

PROVIDER: S-EPMC10711188 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature