Serum branched chain amino acids: an effective indicator of diabetic kidney disease.

ABSTRACT:

Introduction

In recent years, there has been a growing association between elevated circulating levels of branched-chain amino acids (BCAA) and diabetes mellitus. However, the relationship between serum BCAA levels and diabetic kidney disease (DKD) remains ambiguous. This study aims to investigate serum BCAA levels in DKD patients at various stages and assess the correlation between BCAA and clinical characteristics.

Materials and methods

We enrolled patients with type 2 diabetes mellitus (T2DM) who were admitted to our hospital and categorized them into three groups based on different DKD stages: normal proteinuria, microproteinuria, and macroalbuminuria groups. Forty healthy volunteers were included as the control group, and we measured serum BCAA concentrations using liqu

SUBMITTER: Liu M 

PROVIDER: S-EPMC10711269 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature