Body composition and testosterone in men: a Mendelian randomization study.

ABSTRACT:

Background

Testosterone is an essential sex hormone that plays a vital role in the overall health and development of males. It is well known that obesity decreases testosterone levels, but it is difficult to determine the causal relationship between body composition and testosterone.

Methods

To investigate potential causal associations between body composition and testosterone levels by a first time application of Mendelian randomization methods. Exposure variables in men included body composition (fat mass, fat-free mass, and body mass index). In addition to whole body fat and fat-free mass, we examined fat and fat-free mass for each body part (e.g., trunk, left arm, right arm, left leg and right leg) as exposures. Instrumental variables were defined using genome-wide assoc

SUBMITTER: Ikehata Y 

PROVIDER: S-EPMC10711270 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature