Rapid transient and longer-lasting innate cytokine changes associated with adaptive immunity after repeated SARS-CoV-2 BNT162b2 mRNA vaccinations.

ABSTRACT:

Introduction

Cytokines and chemokines play an important role in shaping innate and adaptive immunity in response to infection and vaccination. Systems serology identified immunological parameters predictive of beneficial response to the BNT162b2 mRNA vaccine in COVID-19 infection-naïve volunteers, COVID-19 convalescent patients and transplant patients with hematological malignancies. Here, we examined the dynamics of the serum cytokine/chemokine responses after the 3^rd BNT162b2 mRNA vaccination in a cohort of COVID-19 infection-naïve volunteers.

Methods

We measured serum cytokine and chemokine responses after the 3^rd dose of the BNT162b2 mRNA (Pfizer/BioNtech) vaccine in COVID-19 infection-naïve individuals by a chemiluminescent assay and ELISA. Anti-Sp

SUBMITTER: Rosati M 

PROVIDER: S-EPMC10711274 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature