Genomic analysis of <i>Streptococcus pneumoniae</i> serogroup 20 isolates in Alberta, Canada from 1993-2019.

ABSTRACT: In the province of Alberta, Canada, invasive disease caused by Streptococcus pneumoniae serogroup 20 (serotypes 20A/20B) has been increasing in incidence. Here, we characterize provincial invasive serogroup 20 isolates collected from 1993 to 2019 alongside invasive and non-invasive serogroup 20 isolates from the Global Pneumococcal Sequencing (GPS) Project collected from 1998 to 2015. Trends in clinical metadata and geographic location were evaluated, and serogroup 20 isolate genomes were subjected to molecular sequence typing, virulence and antimicrobial resistance factor mining, phylogenetic analysis and pangenome calculation. Two hundred and seventy-four serogroup 20 isolates from Alberta were sequenced, and analysed along with 95 GPS Project genomes. The majority of invasive Alb

SUBMITTER: Williams AN 

PROVIDER: S-EPMC10711305 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature