Difference in respiratory syncytial virus-specific Fc-mediated antibody effector functions between children and adults.

ABSTRACT: Respiratory syncytial virus (RSV) infections are a major cause of bronchiolitis and pneumonia in infants and older adults, for which there is no known correlate of protection. Increasing evidence suggests that Fc-mediated antibody effector functions have an important role, but little is known about the development, heterogeneity, and durability of these functional responses. In light of future vaccine strategies, a clear view of the immunological background and differences between various target populations is of crucial importance. In this study, we have assessed both quantitative and qualitative aspects of RSV-specific serum antibodies, including IgG/IgA levels, IgG subclasses, antibody-dependent complement deposition, cellular phagocytosis, and NK cell activation (ADNKA). Samples were c

SUBMITTER: Lakerveld AJ 

PROVIDER: S-EPMC10711356 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature