Maternal liver-related symptoms during pregnancy in primary sclerosing cholangitis.

ABSTRACT:

Background & aims

Although worsening liver-related symptoms during pregnancy can occur in primary sclerosing cholangitis (PSC), there are insufficient data to effectively counsel patients on their pre-conception risk and no clear recommendations on monitoring and management during pregnancy. We aimed to describe maternal liver-related symptoms in pregnancy, both before and after PSC diagnosis, and explore factors associated with worsening symptoms and liver-related outcomes.

Methods

We conducted a multicentre retrospective observational study of females with PSC and known pregnancy with live birth, via the International PSC Study Group. We included 450 patients from 12 European centres. Data included clinical variables, liver-related symptoms (pruritus and/or cholangitis) du

SUBMITTER: Nayagam JS 

PROVIDER: S-EPMC10711472 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature