Critical shortfalls in the management of PBC: Results of a UK-wide, population-based evaluation of care delivery.

ABSTRACT:

Background & aims

Guidelines for the management of primary biliary cholangitis (PBC) were published by the British Society of Gastroenterology in 2018. In this study, we assessed adherence to these guidelines in the UK National Health Service (NHS).

Methods

All NHS acute trusts were invited to contribute data between 1 January 2021 and 31 March 2022, assessing clinical care delivered to patients with PBC in the UK.

Results

We obtained data for 8,968 patients with PBC and identified substantial gaps in care across all guideline domains. Ursodeoxycholic acid (UDCA) was used as first-line treatment in 88% of patients (n = 7,864) but was under-dosed in one-third (n = 1,964). Twenty percent of patients who were UDCA-untreated (202/998) and 50% of patients with inadequate U

SUBMITTER: Abbas N 

PROVIDER: S-EPMC10711474 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature