Fine mapping identifies independent HLA associations in autoimmune hepatitis type 1.

ABSTRACT:

Background & aims

Association studies have greatly refined the important role of the major histocompatibility complex (MHC) region in autoimmune hepatitis (AIH). However, the effects of human leucocyte antigen (HLA) polymorphisms on AIH are not well established. The aim of this study is to systematically characterise the association of MHC variants with AIH in our well-defined cohort of patients.

Methods

We performed an imputation-based analysis on the extensive association observed within the MHC region using the Han-MHC reference panel, and tested the comprehensive associations of HLA polymorphisms with AIH in 1622 Chinese AIH type 1 patients and 10,466 population controls.

Results

A total of 588 HLA variants were significantly associated with AIH, with HLA-B∗35:01

SUBMITTER: Li Y 

PROVIDER: S-EPMC10711477 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature