Marked difference in liver fat measured by histology vs. magnetic resonance-proton density fat fraction: A meta-analysis.

ABSTRACT:

Background & aims

Pathologists quantify liver steatosis as the fraction of lipid droplet-containing hepatocytes out of all hepatocytes, whereas the magnetic resonance-determined proton density fat fraction (PDFF) reflects the tissue triacylglycerol concentration. We investigated the linearity, agreement, and correspondence thresholds between histological steatosis and PDFF across the full clinical spectrum of liver fat content associated with non-alcoholic fatty liver disease.

Methods

Using individual patient-level measurements, we conducted a systematic review and meta-analysis of studies comparing histological steatosis with PDFF determined by magnetic resonance spectroscopy or imaging in adults with suspected non-alcoholic fatty liver disease. Linearity was assessed by me

SUBMITTER: Qadri S 

PROVIDER: S-EPMC10711480 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature