Biomarker study of symptomatic intracranial atherosclerotic stenosis in patients with acute ischemic stroke.

ABSTRACT:

Objective

Acute ischemic stroke (AIS) is characterized by high rates of morbidity, disability, mortality, and recurrence, often leaving patients with varying degrees of sequelae. Symptomatic intracranial atherosclerotic stenosis (sICAS) is a significant contributor to AIS pathogenesis and recurrence. The formation and progression of sICAS are influenced by pathways such as lipid metabolism and inflammatory response. Given its high risk of clinical recurrence, timely assessment of intracranial vascular stenosis in AIS is crucial for diagnosing sICAS, treating stroke, and preventing stroke recurrence.

Methods

Fourteen AIS patients were divided into stenosis and control groups based on the presence or absence of intracranial vessel stenosis. Initially, 4D Label-free proteome qu

SUBMITTER: Ding Y 

PROVIDER: S-EPMC10711507 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature