Novel ibuprofen prodrug: A possible promising agent for the management of complications of Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease (AD) is a severe, varied, and complex brain condition that gradually impairs memory and cognitive function. Epidemiological studies have shown that patients who have a history of long-term NSAID use have a decreased risk of developing AD. The objective of this study is to conduct the structural analysis of a novel ibuprofen prodrug and test its anti-Alzheimer's properties.

Methods

Computational and docking studies were conducted using AMBER 18 package. The in-vivo studies were performed using aluminum chloride-induced experimental AD in rats. Adult Wistar rats of either sex were used and treated with aluminum chloride (32.5 mg/kg, p.o) and ibuprofen prodrug (50 mg/kg, p.o) daily for 30 days. The hole-board test and elevated plus maze wer

SUBMITTER: Nayak A 

PROVIDER: S-EPMC10711515 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature