Bringing together scientific disciplines for collaborative undertakings: a vision for advancing the adverse outcome pathway framework.

ABSTRACT:

Background

Decades of research to understand the impacts of various types of environmental occupational and medical stressors on human health have produced a vast amount of data across many scientific disciplines. Organizing these data in a meaningful way to support risk assessment has been a significant challenge. To address this and other challenges in modernizing chemical health risk assessment, the Organisation for Economic Cooperation and Development (OECD) formalized the adverse outcome pathway (AOP) framework, an approach to consolidate knowledge into measurable key events (KEs) at various levels of biological organisation causally linked to disease based on the weight of scientific evidence (http://oe.cd/aops). Currently, AOPs have been considered predominantly in chemical

SUBMITTER: Chauhan V 

PROVIDER: S-EPMC10711570 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature