Centriole elimination during Caenorhabditis elegans oogenesis initiates with loss of the central tube protein SAS-1.

ABSTRACT: In most metazoans, centrioles are lost during oogenesis, ensuring that the zygote is endowed with the correct number of two centrioles, which are paternally contributed. How centriole architecture is dismantled during oogenesis is not understood. Here, we analyze with unprecedent detail the ultrastructural and molecular changes during oogenesis centriole elimination in Caenorhabditis elegans. Centriole elimination begins with loss of the so-called central tube and organelle widening, followed by microtubule disassembly. The resulting cluster of centriolar proteins then disappears gradually, usually moving in a microtubule- and dynein-dependent manner to the plasma membrane. Our analysis indicates that neither Polo-like kinases nor the PCM, which modulate oogenesis centriole elimination in

SUBMITTER: Pierron M 

PROVIDER: S-EPMC10711648 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature