GPNMB⁺ Gal-3⁺ hepatic parenchymal cells promote immunosuppression and hepatocellular carcinogenesis.

ABSTRACT: Hepatocellular carcinoma (HCC) formation is a multi-step pathological process that involves evolution of a heterogeneous immunosuppressive tumor microenvironment. However, the specific cell populations involved and their origins and contribution to HCC development remain largely unknown. Here, comprehensive single-cell transcriptome sequencing was applied to profile rat models of toxin-induced liver tumorigenesis and HCC patients. Specifically, we identified three populations of hepatic parenchymal cells emerging during HCC progression, termed metabolic hepatocytes (HC^Meta ), Epcam⁺ population with differentiation potential (EP^+Diff ) and immunosuppressive malignant transformation subset (MT^Immu ). These distinct subpopulations form an oncogenic

SUBMITTER: Meng Y 

PROVIDER: S-EPMC10711661 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature