The Neurogenome study: Comprehensive molecular profiling to optimize treatment for Danish glioblastoma patients.

ABSTRACT:

Background

Glioblastoma is an aggressive brain cancer with no possibility for cure. Treatment and survival have only improved slightly since 2005 when the current regime was implemented. The limited improvements in the treatment of glioblastoma may reflect our poor understanding of the disease. We hypothesize that systematically collected translational data will improve knowledge and hereby treatment.

Methods

We have been performing whole exome sequencing in glioblastoma tumor tissue since 2016 and whole genome sequencing (WGS) since 2020 with the aim of offering experimental treatment.

Results

We have sequenced 400+ GBM patients and from these 100+ are paired tumor samples from relapse surgery. To develop genomic profiling and to increase the information on each pati

SUBMITTER: Noroxe DS 

PROVIDER: S-EPMC10711669 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature