Familial risk of vasospastic angina: a nationwide family study in Sweden.

ABSTRACT:

Objectives

Vasospastic angina (VSA) is a complex coronary vasomotor disorder associated with an increased risk of myocardial infarction and sudden death. Despite considerable advances in understanding VSA pathophysiology, the interplay between genetic and environmental factors remains elusive. Accordingly, we aimed to determine the familial VSA risk among first-degree relatives of affected individuals.

Methods

A population-based multigenerational cohort study was conducted, including full-sibling pairs born to Swedish parents between 1932 and 2018. Register-based diagnoses were ascertained through linkage to the Swedish Multigeneration Register and National Patient Register. Incidence rate ratios (IRRs) and adjusted HRs were calculated for relatives of individuals with VSA c

SUBMITTER: Ricci F 

PROVIDER: S-EPMC10711886 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature