Causal effects of gut microbiome on hypertension: a Mendelian randomization study.

ABSTRACT:

Background

Previous observational studies have shown that there is an important relationship between gut microbiota and hypertension, we performed a two-sample Mendelian randomization analysis to examine whether the gut microbiota is causally related to hypertension in order to find a basis for potential diagnostic or intervention approaches for hypertension.

Methods

We obtained significant single nucleotide polymorphisms related to gut microbiota and hypertension from publicly available genome-wide association studies for a two-sample Mendelian randomization study. A total of 18,340 individual genome-wide genotype data were included from 24 population-based cohorts. The inverse-variance weighted meta-analysis is the main analytical method for evaluating causal relationships

SUBMITTER: He G 

PROVIDER: S-EPMC10712025 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature