Genetic variants in myostatin and its receptors promote elite athlete status.

ABSTRACT:

Background

While product of the myostatin gene (MSTN) is an important factor influencing muscle growth, which is well confirmed in nonhuman species, it has not been clearly confirmed whether MSTN expression influences interindividual differences in skeletal muscle mass, affects posttraining changes, or plays a role in the age-related loss of muscle mass and function in humans. Although the inconclusive results are usually explained by ethnic differences and the low frequency of some alleles, it is possible that the role of receptors (ACVR2A and ACVR2B) that affect the biological activity of myostatin is crucial. Therefore, we investigated the sequences of the MSTN, ACVR2A, and ACVR2B genes and determined the interaction between allelic variants and athletic performance and competit

SUBMITTER: Leonska-Duniec A 

PROVIDER: S-EPMC10712039 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature