Y chromosome AZFc microdeletion may have negative effect on embryo euploidy: a retrospective cohort study.

ABSTRACT:

Background

Embryo aneuploidy is a main of principal reason of pregnancy loss, in vitro fertilization (IVF) failure and birth defects in offspring. Previous researchs have demonstrated that Y chromosome AZFc microdeletion was associated with reproduction outcomes, however, the relationship between Y chromosome AZFc microdeletion and embryo aneuploidy remains unexplored.

Methods

This retrospective cohort study enrolled 513 patients with 603 cycles in the reproductive center of Nanjing Maternity and Child Health Care Hospital from January 1, 2016 to June 30, 2022. The study cohort was divided into two groups: the AZFc microdeletion group, comprising 53 patients and 58 cycles, and the control group, comprising 460 patients and 545 cycles. Statistical methods including restricted

SUBMITTER: Jiang W 

PROVIDER: S-EPMC10712062 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature