A pan-cancer analysis of Dyskeratosis congenita 1 (DKC1) as a prognostic biomarker.

ABSTRACT:

Background

Dyskeratosis congenita 1 (DKC1), a critical component of telomerase complex, is highly expressed in a variety of human cancers. However, the association of DKC1 with cancer occurrence and development stages is not clear, making a pan-cancer analysis crucial.

Methods

We conducted a study using various bioinformatic databases such as TIMER, GEPIA, UALCAN, and KM plotter Analysis to examine the different expressions of DKC1 in multiple tissues and its correlation with pathological stages. Through KEGG analysis, GO enrichment analysis and Venn analysis, we were able to reveal DKC1-associated genes and signaling pathways. In addition, we performed several tests including the CCK, wound healing assay, cell cycle arrest assay, transwell assay and Sa-β-gal staining on DKC

SUBMITTER: Liu XY 

PROVIDER: S-EPMC10712082 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature