Do we know enough about the effect of low-dose computed tomography screening for lung cancer on mortality to act? An updated systematic review, meta-analysis and network meta-analysis of randomised controlled trials 2017 to 2021.

ABSTRACT:

Background

For people at high risk of lung cancer, low-dose computed tomography (LDCT) is proposed as a method to reduce mortality.

Methods

Our objective was to estimate the effect of LDCT lung cancer screening on mortality in high-risk populations. A systematic review of randomised controlled trials (RCTs) comparing LDCT screening programmes with usual care (no screening) or other imaging screening programme (such as chest X-ray (CXR)) was conducted. RCTs of CXR screening were additionally included in the network meta-analyses. Bibliographic sources including MEDLINE, Embase, Web of Science and the Cochrane Library were searched to January 2017, and then further extended to November 2021. All key review steps were done by two persons. Quality assessment used the Cochrane Ri

SUBMITTER: Duer E 

PROVIDER: S-EPMC10712083 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature