The preprogrammed anti-inflammatory phenotypes of CD11c^high macrophages by Streptococcus pneumoniae aminopeptidase N safeguard from allergic asthma.

ABSTRACT:

Background

Early microbial exposure is associate with protective allergic asthma. We have previously demonstrated that Streptococcus pneumoniae aminopeptidase N (PepN), one of the pneumococcal components, inhibits ovalbumin (OVA) -induced airway inflammation in murine models of allergic asthma, but the underlying mechanism was incompletely determined.

Methods

BALB/c mice were pretreated with the PepN protein and exposed intranasally to HDM allergen. The anti-inflammatory mechanisms were investigated using depletion and adoptive transfer experiments as well as transcriptome analysis and isolated lung CD11c^high macrophages.

Results

We found pretreatment of mice with PepN promoted the proliferation of lung-resident F4/80⁺CD11c^high macroph

SUBMITTER: Yao S 

PROVIDER: S-EPMC10712085 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature