Sex differences in mouse infralimbic cortex projections to the nucleus accumbens shell.

ABSTRACT:

Background

The nucleus accumbens (NAc) is an important region in motivation and reward. Glutamatergic inputs from the infralimbic cortex (ILC) to the shell region of the NAc (NAcSh) have been implicated in driving the motivation to seek reward through repeated action-based behavior. While this has primarily been studied in males, observed sex differences in motivational circuitry and behavior suggest that females may be more sensitive to rewarding stimuli. These differences have been implicated for the observed vulnerability in women to substance use disorders.

Methods

We used an optogenetic self-stimulation task in addition to ex vivo electrophysiological recordings of NAcSh neurons in mouse brain slices to investigate potential sex differences in ILC-NAcSh circuitry in rew

SUBMITTER: Johnson CS 

PROVIDER: S-EPMC10712109 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature