The epidemiology of primary FSGS including cluster analysis over a 20-year period.

ABSTRACT:

Introduction

Focal segmental glomerulosclerosis (FSGS) is one of the leading causes of nephrotic syndrome in adults. This epidemiological study describes a renal centre's 20-year experience of primary FSGS.

Methods

Patients were identified with a diagnosis of primary FSGS after exclusion of known secondary causes. In this retrospective observational study, data was collected for baseline demographics, immunosuppression and outcomes. A two-step cluster analysis was used to identify natural groupings within the dataset.

Results

The total cohort was made up of 87 patients. Those who received immunosuppression had lower median serum albumin than those who did not- 23g/L vs 40g/L (p<0.001) and higher median urine protein creatinine ratios (uPCR)- 795mg/mmol vs 318mg/mmol (

SUBMITTER: McDonnell T 

PROVIDER: S-EPMC10712143 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature