Medrysone promotes corneal injury repair by promoting M2-like polarization of macrophages.

ABSTRACT:

Background

Accumulated evidence suggests that M2-like polarized macrophages plays an important role in reducing inflammation, promoting and accelerating wound healing process and tissue repair. Thus, M2-like TAMs (Tumour-associated macrophages) was an appealing target for therapy intervention.

Method

Flow cytometry and RT-PCR assay were used to detect the polarization of macrophages induced by Medrysone, and the rat corneal mechanical injury model was established to evaluate the efficacy of Medrysone in cornel repair.

Results

Here we found that Medrysone enhanced IL-4 induced M2 polarization of macrophages, as illustrated by increased expression of CD206, up-regulation of M2 marker mRNAs. Medrysone promoted VEGF and CCL2 secretion in IL-4 induced M2-like polarization.

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC10712160 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature