Maternal exposure to nano-titanium dioxide impedes fetal development via endothelial-to-mesenchymal transition in the placental labyrinth in mice.

ABSTRACT:

Background

Extensive production and usage of commercially available products containing TiO₂ NPs have led to accumulation in the human body. The deposition of TiO₂ NPs has even been detected in the human placenta, which raises concerns regarding fetal health. Previous studies regarding developmental toxicity have frequently focused on TiO₂ NPs < 50 nm, whereas the potential adverse effects of large-sized TiO₂ NPs received less attention. Placental vasculature is essential for maternal-fetal circulatory exchange and ensuring fetal growth. This study explores the impacts of TiO₂ NPs (100 nm in size) on the placenta and fetal development and elucidates the underlying mechanism from the perspective of placental vasculature. Pregnan

SUBMITTER: Li X 

PROVIDER: S-EPMC10712190 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature