Trimethylamine N-oxide and hip fracture and bone mineral density in older adults: The cardiovascular health study.

ABSTRACT:

Context

Gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) may adversely affect bone by inducing oxidative stress. Whether this translates into increased fracture risk in older adults is uncertain.

Objective

Determine the associations of plasma TMAO with hip fracture and bone mineral density (BMD) in older adults.

Design and setting

Cox hazard models and linear regression stratified by sex examined the associations of TMAO with hip fracture and BMD in the longitudinal cohort of the Cardiovascular Health Study.

Participants

5019 U.S. adults aged ≥65 years.

Exposure

Plasma TMAO.

Main outcome measures

Incident hip fractures; total hip BMD dual x-ray absorptiometry in a subset (n = 1400).

Results

Six hundred sixty-six incident hip

SUBMITTER: Elam RE 

PROVIDER: S-EPMC10712255 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature