Dataset Information
Hematopoietic effect of echinochrome on phenylhydrazine-induced hemolytic anemia in rats.
Ontology highlight
ABSTRACT: Background
Hemolytic anemia (HA) is a serious health condition resulting from reduced erythrocytes' average life span. Echinochrome (Ech) is a dark-red pigment found in shells and spines of sea urchins.Aim
Studying the potential therapeutic effect of Ech on phenylhydrazine (PHZ)-induced HA in rats.Methods
Eighteen rats were divided into three groups (n = 6): the control group, the phenylhydrazine-induced HA group and the Ech group, injected intraperitoneally with PHZ and supplemented with oral Ech daily for 6 days.Results
Ech resulted in a considerable increase in RBCs, WBCs, and platelets counts, hemoglobin, reduced glutathione, catalase, and glutathione-S-transferase levels, and a significant decrease in aspartate & alanine aminotransferases, alkaline phosphatase, gamma-glutamyl transferase, bilirubin, creatinine, urea, urate, malondialdehyde & nitric oxide levels in anemic rats. Histopathological examination of liver and kidney tissue samples showed marked improvement.Conclusion
Ech ameliorated phenylhydrazine-induced HA with a hepatorenal protective effect owing to its anti-inflammatory and antioxidant properties.
SUBMITTER: El-Shehry MSEF
PROVIDER: S-EPMC10712303 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Publications
Hematopoietic effect of echinochrome on phenylhydrazine-induced hemolytic anemia in rats.
PeerJ 20231208
<h4>Background</h4>Hemolytic anemia (HA) is a serious health condition resulting from reduced erythrocytes' average life span. Echinochrome (Ech) is a dark-red pigment found in shells and spines of sea urchins.<h4>Aim</h4>Studying the potential therapeutic effect of Ech on phenylhydrazine (PHZ)-induced HA in rats.<h4>Methods</h4>Eighteen rats were divided into three groups (<i>n</i> = 6): the control group, the phenylhydrazine-induced HA group and the Ech group, injected intraperitoneally with P ...[more]
