The association of prenatal manganese exposure with problem-solving skills and its mediation by the building blocks of executive function.

ABSTRACT:

Background

Problem-solving skills build upon three core executive functions: inhibition, working memory, and cognitive flexibility. There is evidence of adverse associations of prenatal exposure to manganese (Mn) with core executive functions, but less is known about Mn associations with problem-solving or potential mediators of this association.

Objectives

This study aimed to investigate the association of prenatal Mn exposure with problem-solving and to identify potential neuropsychological mechanisms through which this association may be mediated.

Methods

Study participants were 410 adolescents from the New Bedford Cohort (NBC) who have undergone periodic evaluations since their birth (1993-1998) to mothers residing near a Massachusetts Superfund site. We investiga

SUBMITTER: Oppenheimer AV 

PROVIDER: S-EPMC10712564 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature