Characterization of hemodynamics in anomalous aortic origin of coronary arteries using patient-specific modeling.

ABSTRACT: The anomalous aortic origin of coronary arteries (AAOCA) is a congenital disease that can lead to sudden cardiac death (SCD) during strenuous physical activity. Despite AAOCA being the second leading cause of SCD among young athletes, the mechanism behind sudden cardiac death remains mostly unknown. Computational fluid dynamics provides a powerful tool for studying how pathologic anatomy can affect different hemodynamic states. The present study investigates the effect of AAOCA on patient hemodynamics. We performed patient-specific hemodynamic simulations of interarterial AAOCA at baseline and in the exercise state using our massively parallel flow solver. Additionally, we investigate how surgical correction via coronary unroofing impacts patient blood flow. Results show that patient-speci

SUBMITTER: Chidyagwai SG 

PROVIDER: S-EPMC10712838 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature