Post-stress changes in the gut microbiome composition in rats with different levels of nervous system excitability.

ABSTRACT: The gut-brain axis is a critical communication system influencing the interactions between the gastrointestinal tract (GI) and the central nervous system (CNS). The gut microbiota plays a significant role in this axis, affecting the development and function of the nervous system. Stress-induced psychopathologies, such as depression and anxiety, have been linked to the gut microbiota, but underlying mechanisms and genetic susceptibility remain unclear. In this study, we examined stress-induced changes in the gut microbiome composition in two rat strains with different levels of nervous system excitability: high threshold (HT strain) and low threshold (LT strain). Rats were exposed to long-term emotional and painful stress using the Hecht protocol, and fecal samples were collected at multipl

SUBMITTER: Shevchenko A 

PROVIDER: S-EPMC10712864 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature