Age-Related Alterations in Peripheral Immune Landscape with Magnified Impact on Post-Stroke Brain.

ABSTRACT: Immunosenescence refers to the multifaceted and profound alterations in the immune system brought about by aging, exerting complex influences on the pathophysiological processes of diseases that manifest upon it. Using a combination of single-cell RNA sequencing, cytometry by time of flight, and various immunological assays, we investigated the characteristics of immunosenescence in the peripheral blood of aged mice and its impact on the cerebral immune environment after ischemic stroke. Our results revealed some features of immunosenescence. We observed an increase in neutrophil counts, concurrent with accelerated neutrophil aging, characterized by altered expression of aging-associated markers like CD62L and consequential changes in neutrophil-mediated immune functions. Monocytes/macroph

SUBMITTER: Lu J 

PROVIDER: S-EPMC10712880 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature