Analysis of Rare Variants in 470,000 Exome-Sequenced UK Biobank Participants Implicates Novel Genes Affecting Risk of Hypertension.

ABSTRACT:

Introduction

A previous study of 200,000 exome-sequenced UK Biobank participants to test for association of rare coding variants with hypertension implicated two genes at exome-wide significance, DNMT3A and FES. A total of 42 genes had an uncorrected p value <0.001. These results were followed up in a larger sample of 470,000 exome-sequenced participants.

Methods

Weighted burden analysis of rare coding variants in a new sample of 97,050 cases and 172,263 controls was carried out for these 42 genes. Those showing evidence for association were then analysed in the combined sample of 167,127 cases and 302,691 controls.

Results

The association of DNMT3A and FES with hypertension was replicated in the new sample and they and the previousl

SUBMITTER: Curtis D 

PROVIDER: S-EPMC10712968 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature