The Impact of Pathogen Reduction on Total IgG and IgG Subclass Profiles of Convalescent Plasma.

ABSTRACT:

Introduction

In case of newly emerging pathogens, convalescent plasma (CP) is often the only early available treatment option. It has been shown that different IgG subclasses contribute differently to CP neutralizing activity. As CP donors often have a risk profile like first-time donors, especially with respect to window-period viral transmission, pathogen reduction (PR) could mitigate that risk. The aim of our study, especially in the light of potential future pandemics, was to evaluate the impact of commercially available PR technologies on total IgG and IgG subclasses quantity and distribution in CP using COVID-19 CP (CCP) as surrogate for CP in a side-by-side comparison approach.

Methods

36 apheresis CCP donations were allocated to three study groups and a side-by-side

SUBMITTER: Wasiluk T 

PROVIDER: S-EPMC10712978 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature