Potential drug targets for myocardial infarction identified through Mendelian randomization analysis and Genetic colocalization.

ABSTRACT: Myocardial infarction (MI) is a major cause of death and disability worldwide, but current treatments are limited by their invasiveness, side effects, and lack of efficacy. Novel drug targets for MI prevention are urgently needed. In this study, we used Mendelian randomization to identify potential therapeutic targets for MI using plasma protein quantitative trait loci as exposure variables and MI as the outcome variable. We further validated our findings using reverse causation analysis, Bayesian co-localization analysis, and external datasets. We also constructed a protein-protein interaction network to explore the relationships between the identified proteins and known MI targets. Our analysis revealed 2 proteins, LPA and APOA5, as potential drug targets for MI, with causal effects on M

SUBMITTER: Wu J 

PROVIDER: S-EPMC10713171 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature