Comparative bioinformatics analysis of transcriptomes between β-aminopropionitrile-induced aortic dissection murine model and human aortic dissection.

ABSTRACT:

Background

Aortic dissection (AD) poses a great threat to the life of patients; however, there is currently no documentation of a clear pathogenic mechanism of this disease. In recent years, β-aminopropionitrile (BAPN)-induced AD in rodents has been widely used in basic research, which provides a good platform for exploring the pathogenesis of AD and drug modification. This study aimed to identify molecular markers and pathways for the diagnosis and treatment of AD by comparing a murine AD model and human AD transcriptome through a bioinformatics analysis.

Methods

We constructed a BAPN-induced mice model and performed high-throughput sequencing analysis. The GSE147026 dataset of patients was obtained from the Gene Expression Omnibus database. We performed a subsequent bioinf

SUBMITTER: Hu K 

PROVIDER: S-EPMC10713304 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature