Serum iron status and the risk of lung cancer: a two-sample Mendelian-randomization study.

ABSTRACT:

Background

Previous epidemiological studies have reported controversial findings about the potential causal association between iron status and lung cancer. This study sought to assess the potential causality of serum iron status and lung cancer using the Mendelian-randomization (MR) method.

Methods

We selected the genetic variables for iron status from the Genetics of Iron Status (GIS) consortium comprising 48,972 samples from European populations. The following two analysis strategies for instrumental variables (IVs) were applied: a conservative approach (instruments related to four iron status markers), and a liberal approach (instruments related to each iron status marker). The summary-level data for lung cancer were obtained from the International Lung Cancer Consortium

SUBMITTER: Feng X 

PROVIDER: S-EPMC10713307 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature