A novel telomere-related genes model for predicting prognosis and treatment responsiveness in diffuse large B-cell lymphoma.

ABSTRACT: Diffuse large B cell lymphoma (DLBCL) is a highly heterogeneous disease with diverse clinical and molecular features. Telomere maintenance is widely present in tumors, but there is a lack of relevant reports on the role of telomere-related genes (TRGs) in DLBCL. In this study, we used consensus clustering based on TRGs expression to identify two molecular clusters with distinct prognoses and immune cell infiltration. We developed a TRGs scoring model using univariate Cox regression and LASSO regression in the GSE10846 training cohort. DLBCL patients in the high-risk group had a worse prognosis than those in the low-risk group, as revealed by Kaplan-Meier curves. The scoring model was validated in the GSE10846 testing cohort and GSE87371 cohort, respectively. The high-risk group was charact

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC10713390 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature