Peptidome analysis reveals critical roles for peptides in a rat model of intestinal ischemia/reperfusion injury.

ABSTRACT: Intestinal ischemia/reperfusion injury (IIRI) has the potential to be life threatening and is associated with significant morbidity and serious damage to distant sites in the body on account of disruption of the intestinal mucosal barrier. In the present study, we have explored this line of research by comparing and identifying peptides that originated from the intestinal segments of IIRI model rats by using liquid chromatography-mass spectrometry (LC-MS). We also analyzed the basic characteristics, cleavage patterns, and functional domains of differentially expressed peptides (DEPs) between the IIRI model rats and control (sham-operated) rats and identified bioactive peptides that are potentially associated with ischemia reperfusion injury. We also performed bioinformatics analyses in ord

SUBMITTER: Zhang J 

PROVIDER: S-EPMC10713420 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature