Long non-coding RNA EGOT is associated with ¹³¹iodine sensitivity and contributes to thyroid cancer progression by targeting miR-641/PTEN axis.

ABSTRACT: Thyroid cancer is a prevalent endocrine malignancy around the world. Radioactive ¹³¹iodine (¹³¹I) therapy is widely applied in TC patients, but the resistance affects its effectiveness in the clinics. Long non-coding RNA (lncRNA) EGOT has been reported to induce an inhibitory effect on cancer progression, but the specific function of EGOT in ¹³¹I resistance of TC cells remains unclear. Here, we successfully established ¹³¹I-resistant TC cells and evaluated the impact of EGOT on ¹³¹I resistance in the cells. Our data showed that EGOT and PTEN expression was reduced but the miR-641 expression was enhanced in ¹³¹I-resistant TC cells. EGOT inhibited viability, induced apoptosis and enhanced DNA damage in ¹³¹I-resistan

SUBMITTER: Wang M 

PROVIDER: S-EPMC10713430 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature