Nectandrin B significantly increases the lifespan of Drosophila - Nectandrin B for longevity.

ABSTRACT: Phytochemicals are increasingly recognized in the field of healthy aging as potential therapeutics against various aging-related diseases. Nutmeg, derived from the Myristica fragrans tree, is an example. Nutmeg has been extensively studied and proven to possess antioxidant properties that protect against aging and alleviate serious diseases such as cancer, heart disease, and liver disease. However, the specific active ingredient in nutmeg responsible for these health benefits has not been identified thus far. In this study, we present evidence that Nectandrin B (NecB), a bioactive lignan compound isolated from nutmeg, significantly extended the lifespan of the fruit fly Drosophila melanogaster by as much as 42.6% compared to the control group. NecB also improved age-related s

SUBMITTER: Ahn JS 

PROVIDER: S-EPMC10713431 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature