Identifying primary aldosteronism patients who require adrenal venous sampling: a multi-center study.

ABSTRACT: Adrenal venous sampling (AVS) is crucial for subtyping primary aldosteronism (PA) to explore the possibility of curing hypertension. Because AVS availability is limited, efforts have been made to develop strategies to bypass it. However, it has so far proven unsuccessful in applying clinical practice, partly due to heterogeneity and missing values of the cohorts. For this purpose, we retrospectively assessed 210 PA cases from three institutions where segment-selective AVS, which is more accurate and sensitive for detecting PA cases with surgical indications, was available. A machine learning-based classification model featuring a new cross-center domain adaptation capability was developed. The model identified 102 patients with PA who benefited from surgery in the present cohort. A new dat

SUBMITTER: Kitamoto T 

PROVIDER: S-EPMC10713522 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature